Positive regulation of muscle hypertrophy

Across TCGA cell cohorts, RNA activity of the Positive regulation of muscle hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CAMK2D, OSBPL8, and ROCK1, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of muscle hypertrophy activity versus CAMK2D in BONE (Pearson r = 0.61).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CAMK2D →	+2.466	+0.213	<.001	<.001	3	13
BLOOD_Lymphoma	OSBPL8 →	+0.974	+0.072	<.001	.001	3	12
LARGE_INTESTINE	ROCK1 →	+0.871	+0.066	<.001	.001	3	11
BONE	PRKCA →	+1.787	+0.155	<.001	<.001	3	11
BLOOD_Leukemia	WASHC4 →	+0.715	+0.064	<.001	<.001	3	11
BLOOD_Lymphoma	ROCK2 →	+0.934	+0.089	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014742 vs CAMK2D — BONE

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