Skeletal muscle satellite cell activation

Across TCGA patient cohorts, RNA activity of the Skeletal muscle satellite cell activation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NIFK, UTP15, and HK2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Skeletal muscle satellite cell activation activity versus NIFK in HNSC (Pearson r = -0.14).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	NIFK →	+0.335	+0.094	<.001	<.001	3	6
LSCC	UTP15 →	+0.221	+0.082	.009	.002	3	5
LSCC	HK2 →	+0.568	+0.120	<.001	<.001	3	5
BRCA	RRP36_S73 →	+0.515	+0.042	.002	.006	3	5
BRCA	SH3BGRL →	-0.481	-0.039	<.001	.001	3	5
BRCA	XRCC6_T455 →	+0.501	+0.046	<.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014719 vs NIFK — HNSC

Explore this scatter interactively →