Response to amine

Across TCGA patient cohorts, RNA activity of the Response to amine pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LTBP2, NCF4, and HIC1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to amine activity versus LTBP2 in BRCA (Pearson r = -0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LTBP2 →	-0.852	-0.151	.002	<.001	3	5
GBM	NCF4 →	-0.672	-0.129	.001	.008	3	5
GBM	HIC1 →	-0.530	-0.148	.001	.002	3	5
GBM	TGM2 →	-0.596	-0.099	.003	.007	3	5
BRCA	MYH9 →	-0.529	-0.112	<.001	.005	3	4
GBM	LOXL1 →	-0.798	-0.140	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014075 vs LTBP2 — BRCA

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