Response to amine

Across TCGA pan-cancer cohorts, RNA activity of the Response to amine pathway is associated with patient survival in 18 of 34 cancer lineages. Pathway activity is summarized from the expression of its 47 member genes.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher Response to amine pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD, show the opposite pattern, with higher activity associated with better survival.

ACC, MESO, and ESCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	All	0.339	0.769	<.001	113	view →
MESO	DFS	Median	II,III,IV	0.297	0.505	.002	66	view →
ESCA	OS	Median	All	0.407	1.000	.003	46	view →
DLBC	DFS	Median	All	0.593	0.879	.011	32	view →
SCLC	DFS	Median	All	0.508	0.709	.006	30	view →
OV	OS	Quartile	IV	0.405	0.707	.013	26	view →
COAD	OS	Tertile	III,IV	0.879	0.643	.006	23	view →
CHOL	DFS	Quartile	II,III,IV	0.043	0.554	.010	18	view →
KIRP	OS	Quartile	All	0.471	0.834	.011	17	view →
THCA	OS	Tertile	III,IV	0.949	1.000	.009	14	view →
BRCA	OS	Tertile	IV	0.456	0.833	.038	12	view →
SKCM	DFS	Median	All	0.156	0.295	.001	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

GO:0014075–ACC (OS)

Open the ACC breakdown →