Neural crest cell fate commitment

Across TCGA cell cohorts, RNA activity of the Neural crest cell fate commitment pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EAF2, GSPT1, and VEGFA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EAF2 grouped by Neural crest cell fate commitment-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	EAF2 →	+0.695	+0.867	<.001	<.001	3	3
LIVER	GSPT1 →	+0.843	+1.582	.005	.005	3	3
LIVER	VEGFA →	-1.396	-1.594	.007	.001	3	3
LIVER	TKT →	-1.693	-1.455	.001	.009	3	3
LIVER	MTURN →	-1.196	-1.503	.008	.004	3	3
LUNG_NSCLC_LUAD	INO80D →	+0.374	+0.485	.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EAF2 by Neural crest cell fate commitment activity — OVARY

Explore this box plot interactively →