Regulation of gliogenesis

Across TCGA patient cohorts, RNA activity of the Regulation of gliogenesis pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RN7SL334P, GLRB, and ZAP70, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gliogenesis activity versus RN7SL334P in HNSC (Pearson r = 0.24).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL334P →	+0.764	+0.145	.004	.001	3	4
PDAC	GLRB →	-0.595	-0.209	.001	<.001	3	3
HNSC	ZAP70 →	+0.896	+0.148	<.001	<.001	3	3
PDAC	PDE5A →	-0.333	-0.154	<.001	<.001	3	3
PDAC	SLC43A2 →	+0.422	+0.171	<.001	.007	3	3
PDAC	NCR3 →	+0.459	+0.211	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014013 vs RN7SL334P — HNSC

Explore this scatter interactively →