Regulation of gliogenesis

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of gliogenesis pathway is associated with patient survival in 16 of 34 cancer lineages. Pathway activity is summarized from the expression of its 108 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Regulation of gliogenesis pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SKCM, show the opposite pattern, with higher activity associated with better survival.

HNSC, SKCM, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.678	0.408	<.001	86	view →
SKCM	OS	Median	All	0.436	0.268	<.001	52	view →
THCA	OS	Median	III,IV	0.886	1.000	.001	34	view →
LGG	OS	Median	All	0.939	0.841	.001	29	view →
OV	DFS	Tertile	IV	0.310	0.533	.035	14	view →
ACC	OS	Median	IV	0.326	0.717	.003	12	view →
KIRC	DFS	Quartile	All	0.498	0.672	.029	7	view →
READ	OS	Quartile	III,IV	0.565	0.969	.015	6	view →
SARC	OS	Quartile	All	0.838	0.699	.016	6	view →
STAD	DFS	Median	IV	0.664	0.267	.035	6	view →
BRCA	OS	Median	IV	0.372	0.685	.035	5	view →
DLBC	DFS	Tertile	II,III,IV	0.416	0.956	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

GO:0014013–HNSC (OS)

Open the HNSC breakdown →