Free ubiquitin chain polymerization

Across TCGA patient cohorts, RNA activity of the Free ubiquitin chain polymerization pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMC2, SMC4, and CHAF1B_S410, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Free ubiquitin chain polymerization activity versus SMC2 in UCEC (Pearson r = 0.63).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMC2 →	+0.569	+0.098	<.001	<.001	3	6
LUAD	SMC4 →	+0.430	+0.062	<.001	<.001	3	6
PDAC	CHAF1B_S410 →	+0.638	+0.078	<.001	<.001	3	6
UCEC	MAD2L1 →	+0.379	+0.061	<.001	<.001	3	6
LUAD	MELK_S336 →	+1.049	+0.100	.004	<.001	3	6
LUAD	RRM2 →	+0.609	+0.074	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010994 vs SMC2 — UCEC

Explore this scatter interactively →