Free ubiquitin chain polymerization

Across TCGA pan-cancer cohorts, RNA activity of the Free ubiquitin chain polymerization pathway is associated with patient survival in 23 of 34 cancer lineages. Pathway activity is summarized from the expression of its 9 member genes.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher Free ubiquitin chain polymerization pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as UCS and DLBC, show the opposite pattern, with higher activity associated with better survival.

LIHC, LUAD, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.574	0.754	<.001	72	view →
LUAD	DFS	Median	All	0.579	0.735	<.001	64	view →
ACC	DFS	Quartile	All	0.186	0.651	<.001	63	view →
THCA	OS	Tertile	II,III,IV	0.328	1.000	.004	43	view →
UVM	DFS	Tertile	III,IV	0.211	0.722	.001	42	view →
LGG	DFS	Tertile	All	0.658	0.816	.001	31	view →
OV	OS	Median	II,III,IV	0.655	0.722	.010	26	view →
LUSC	OS	Tertile	All	0.742	0.925	.009	23	view →
PAAD	DFS	Median	All	0.205	0.352	.004	22	view →
SKCM	OS	Tertile	All	0.251	0.377	.005	20	view →
PRAD	DFS	Median	All	0.699	0.860	<.001	18	view →
KIRP	DFS	Quartile	All	0.810	0.973	<.001	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

GO:0010994–LIHC (OS)

Open the LIHC breakdown →