Regulation of low-density lipoprotein particle clearance

Across TCGA patient cohorts, RNA activity of the Regulation of low-density lipoprotein particle clearance pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LRRC77P, MAN1C1, and OTULINL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of low-density lipoprotein particle clearance activity versus LRRC77P in PDAC (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LRRC77P →	+0.126	+0.203	<.001	<.001	3	5
BRCA	MAN1C1 →	+0.770	+0.185	<.001	<.001	3	4
BRCA	OTULINL →	+0.461	+0.102	.001	.002	3	4
BRCA	SVEP1 →	+1.064	+0.149	<.001	.004	3	4
BRCA	GOLIM4 →	+0.660	+0.149	.002	.002	3	4
LSCC	NRP1 →	+0.479	+0.138	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010988 vs LRRC77P — PDAC

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