Regulation of microtubule nucleation

Across TCGA patient cohorts, RNA activity of the Regulation of microtubule nucleation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPSB2, MIR181D, and RAX, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule nucleation activity versus TPSB2 in PDAC (Pearson r = -0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	TPSB2 →	-0.637	-0.971	.006	<.001	3	3
HNSC	MIR181D →	+0.501	+0.305	.004	.009	3	3
LSCC	RAX →	+0.035	+0.497	.003	.003	3	2
LSCC	RNU6-790P →	-0.599	-0.552	.002	.002	3	2
LSCC	ATP5PBP3 →	+0.341	+0.539	.004	<.001	3	2
LSCC	MIR6876 →	-0.472	-0.392	.003	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010968 vs TPSB2 — PDAC

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