Regulation of microtubule nucleation

Across TCGA patient cohorts, RNA activity of the Regulation of microtubule nucleation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1orf226_S249, RRBP1_S533, and SEC16A_S1347, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of microtubule nucleation activity versus C1orf226_S249 in OV (Pearson r = -0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1orf226_S249 →	-0.974	-1.524	<.001	<.001	3	3
LSCC	RRBP1_S533 →	-1.793	-0.905	<.001	<.001	3	2
LSCC	SEC16A_S1347 →	-0.945	-0.628	<.001	<.001	3	2
COAD	SYNPO2_Y622 →	+0.908	+1.099	<.001	<.001	3	2
LUAD	THSD1_S453 →	-0.624	-0.909	.001	<.001	3	2
LSCC	TNS1_S433 →	+0.762	+0.580	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010968 vs C1orf226_S249 — OV

Explore this scatter interactively →