Regulation of phosphate transport

Across TCGA patient cohorts, RNA activity of the Regulation of phosphate transport pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are COL5A2, PELATON, and LRRC15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of phosphate transport activity versus COL5A2 in GBM (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	COL5A2 →	+1.105	+0.163	.001	.002	3	5
GBM	PELATON →	+0.686	+0.209	.002	<.001	3	4
HNSC	LRRC15 →	+1.725	+0.883	<.001	<.001	3	4
HNSC	THBS2 →	+1.219	+0.673	.001	.001	3	4
CCRCC	ANKRD54 →	-0.265	-0.461	.003	.002	3	4
BRCA	ZNF589 →	-0.387	-0.493	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010966 vs COL5A2 — GBM

Explore this scatter interactively →