Magnesium ion homeostasis

Across TCGA cell cohorts, RNA activity of the Magnesium ion homeostasis pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNNM4, PTH, and XK, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNNM4 grouped by Magnesium ion homeostasis-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CNNM4 →	-0.300	-1.393	<.001	<.001	3	9
BREAST	PTH →	-0.181	-0.664	<.001	<.001	3	8
LUNG_SCLC	XK →	-0.242	-1.083	<.001	.003	3	7
CNS	CNNM2 →	-0.156	-0.990	<.001	<.001	3	7
BLOOD_Myeloma	TLL2 →	-0.443	-1.224	.001	.009	3	5
LIVER	TLX3 →	-0.352	-1.573	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNNM4 by Magnesium ion homeostasis activity — LARGE_INTESTINE

Explore this box plot interactively →