Negative regulation of phosphatase activity

Across TCGA cell cohorts, RNA activity of the Negative regulation of phosphatase activity pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTP4A2, TNFRSF21, and SEC23A, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of phosphatase activity activity versus PTP4A2 in LUNG_NSCLC_LUAD (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PTP4A2 →	+0.829	+1.300	.001	<.001	3	4
KIDNEY	TNFRSF21 →	+2.890	+1.760	.007	<.001	3	3
LARGE_INTESTINE	SEC23A →	+0.803	+0.860	.002	.004	3	3
LARGE_INTESTINE	TXNIP →	-2.113	-1.092	.004	<.001	3	3
OVARY	OSTC →	+1.128	+1.122	.001	.005	3	3
OVARY	HSPA5 →	+1.224	+1.159	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010923 vs PTP4A2 — LUNG_NSCLC_LUAD

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