Negative regulation of phosphatase activity

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of phosphatase activity pathway is associated with patient survival in 26 of 34 cancer lineages. Pathway activity is summarized from the expression of its 24 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Negative regulation of phosphatase activity pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and BRCA, show the opposite pattern, with higher activity associated with better survival.

HNSC, LGG, and UCEC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.427	0.239	<.001	136	view →
LGG	OS	Median	All	0.732	0.872	<.001	48	view →
UCEC	DFS	Quartile	All	0.757	0.901	<.001	46	view →
COAD	OS	Quartile	III,IV	0.532	0.926	.002	46	view →
ACC	DFS	Quartile	II,III,IV	0.262	0.695	.001	43	view →
LIHC	DFS	Quartile	All	0.188	0.337	.001	42	view →
BRCA	OS	Median	All	0.976	0.949	.001	38	view →
BLCA	OS	Median	All	0.733	0.464	.002	34	view →
KICH	DFS	Tertile	All	0.648	0.968	.005	30	view →
KIRP	DFS	Quartile	II,III,IV	0.126	0.833	.004	29	view →
THCA	OS	Quartile	II,III,IV	0.738	1.000	.008	21	view →
SKCM	OS	Median	All	0.835	0.730	<.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

GO:0010923–HNSC (DFS)

Open the HNSC breakdown →