Regulation of very-low-density lipoprotein particle remodeling

Across TCGA patient cohorts, RNA activity of the Regulation of very-low-density lipoprotein particle remodeling pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS16P2, PAH, and PLIN5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of very-low-density lipoprotein particle remodeling activity versus RPS16P2 in PDAC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	RPS16P2 →	+0.370	+0.083	.002	.003	3	4
PDAC	PAH →	-0.856	-0.073	<.001	.001	3	3
PDAC	PLIN5 →	-0.514	-0.088	.003	.004	3	3
PDAC	MEF2C-AS1 →	+0.265	+0.079	.001	.003	3	3
GBM	RNU6-667P →	+0.543	+0.097	.006	<.001	3	3
OV	SNHG25 →	-1.003	-0.152	.002	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010901 vs RPS16P2 — PDAC

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