Negative regulation of sequestering of triglyceride

pathway activity — cross-omics
GO:0010891Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Negative regulation of sequestering of triglyceride pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRYL1, SIN3A_S832, and ZNF532_S298, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMCRYL1 →+0.323+0.055.008.00227
BRCASIN3A_S832 →-0.252-0.032.002.00336
GBMZNF532_S298 →-0.431-0.071<.001<.00135
HNSCSCIN →+0.613+0.074<.001<.00135
LSCCEPB41L1_S75 →+0.544+0.056.009<.00135
LUADDDX20_S714 →-0.363-0.044.006.00935
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration