Positive regulation of sequestering of triglyceride

Across TCGA patient cohorts, RNA activity of the Positive regulation of sequestering of triglyceride pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VDAC2_S115, DAB2, and ACP5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of sequestering of triglyceride activity versus VDAC2_S115 in LSCC (Pearson r = -0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	VDAC2_S115 →	-0.590	-0.081	.001	.001	3	6
GBM	DAB2 →	+0.511	+0.060	<.001	<.001	3	6
LSCC	ACP5 →	+0.456	+0.070	<.001	.002	3	5
LSCC	VAT1 →	+0.345	+0.134	<.001	<.001	3	5
GBM	CTSZ →	+0.426	+0.064	<.001	<.001	3	5
LSCC	CYP27A1 →	+0.411	+0.085	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010890 vs VDAC2_S115 — LSCC

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