Negative regulation of lipid storage

Across TCGA patient cohorts, RNA activity of the Negative regulation of lipid storage pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NEK3, ZNF711, and BBIP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of lipid storage activity versus NEK3 in GBM (Pearson r = -0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NEK3 →	-0.467	-0.214	.003	.002	3	5
GBM	ZNF711 →	-0.698	-0.258	<.001	<.001	3	4
LSCC	BBIP1 →	-0.274	-0.203	.003	.004	3	4
GBM	ZC3H13 →	-0.450	-0.226	<.001	<.001	3	4
GBM	LNX2 →	-0.305	-0.226	.007	<.001	3	4
GBM	STOX2 →	-0.721	-0.230	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010888 vs NEK3 — GBM

Explore this scatter interactively →