Negative regulation of lipid storage

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of lipid storage pathway differs between tumor and matched normal tissue in 7 of the 18 cancer types tested.

The strongest signal is observed in colon adenocarcinoma (COAD), where pathway activity is lower in tumor tissue than in matched normal tissue. In most cancer types, this pathway shows higher activity in tumors, although a few cancer types, such as COAD and LUAD, show the opposite pattern, with lower activity in tumor tissue.

COAD, LUAD, and BRCA show the most reproducible tumor–normal differences in pathway activity.

Tumor vs normal pathway activity by lineage

Ranked by sampling consensus. Activity change represents the tumor-versus-normal difference in pathway activity on a log₂ scale. Positive values indicate higher pathway activity in tumor tissue. The reported p-values are derived from the corresponding differential activity tests.

Lineage	Gender	Stage	Activity change	p	Sampling consensus
COAD	All	III,IV	−0.069	<.001	11	view →
LUAD	Female	All	−0.051	<.001	9	view →
BRCA	All	III,IV	−0.088	<.001	6	view →
LUSC	Female	All	−0.076	<.001	5	view →
KIRP	All	All	+0.022	.012	3	view →
CHOL	All	All	−0.040	.006	2	view →
LIHC	All	II,III,IV	+0.020	.035	1	view →

Pink = more active in tumor, green = less active in tumor. Showing the 7 strongest of 7 lineages.

GO:0010888–COAD

Open the COAD breakdown →