Regulation of cardiac muscle contraction by calcium ion signaling

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle contraction by calcium ion signaling pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL27, FAHD2B, and HBEGF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RPL27 grouped by Regulation of cardiac muscle contraction by calcium ion signaling-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RPL27 →	-0.906	-1.111	<.001	.002	3	4
PANCREAS	FAHD2B →	-1.243	-0.543	<.001	.005	3	3
KIDNEY	HBEGF →	-1.992	-1.081	.002	.009	3	3
STOMACH	GMDS →	-2.558	-0.337	.001	.003	3	3
STOMACH	ROCK2 →	-1.001	-1.045	.004	.006	3	3
STOMACH	PPP1R2 →	-1.153	-0.827	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RPL27 by Regulation of cardiac muscle contraction by calcium ion signaling activity — OVARY

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