Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TMOD2, GUCY1A1, and ANK2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion activity versus TMOD2 in UCEC (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TMOD2 →	+0.492	+0.071	<.001	<.001	3	8
UCEC	GUCY1A1 →	+0.535	+0.097	<.001	.001	3	8
HNSC	ANK2 →	+0.572	+0.095	<.001	<.001	3	8
UCEC	THBS3 →	+0.404	+0.052	.002	.002	3	7
COAD	DPYSL2 →	+0.409	+0.050	<.001	<.001	3	7
UCEC	FERMT2 →	+0.546	+0.079	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010881 vs TMOD2 — UCEC

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