Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 21 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as PAAD and ACC, show the opposite pattern, with higher activity associated with better survival.

UCEC, PAAD, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.793	0.869	.004	50	view →
PAAD	DFS	Quartile	All	0.589	0.223	<.001	41	view →
ACC	OS	Median	All	0.793	0.390	.001	41	view →
THYM	OS	Tertile	All	0.627	0.965	<.001	36	view →
LGG	DFS	Tertile	All	0.275	0.470	<.001	35	view →
READ	OS	Median	II,III,IV	0.467	0.854	.001	32	view →
KIRC	OS	Tertile	All	0.851	0.749	.001	32	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	23	view →
LUAD	DFS	Quartile	II,III,IV	0.795	0.526	.009	23	view →
HNSC	OS	Median	III,IV	0.699	0.419	.001	22	view →
BRCA	OS	Median	All	0.946	0.907	.005	19	view →
LAML	DFS	Median	All	0.224	0.543	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0010881–UCEC (DFS)

Open the UCEC breakdown →