Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Across TCGA patient cohorts, RNA activity of the Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LAMA2, ASPA, and ATP1A2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion activity versus LAMA2 in BRCA (Pearson r = 0.21).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LAMA2 →	+0.897	+0.676	.001	.006	3	7
GBM	ASPA →	+1.119	+0.730	.001	.001	3	7
GBM	ATP1A2 →	+1.384	+0.636	<.001	<.001	3	7
HNSC	CHRDL1 →	+1.482	+0.990	<.001	<.001	3	6
UCEC	PGK1 →	-0.639	-0.513	.006	.002	3	6
GBM	PTGDS →	+1.671	+0.831	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010881 vs LAMA2 — BRCA

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