Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

Across TCGA cell cohorts, RNA activity of the Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SRXN1, TTLL12, and DGLUCY, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion activity versus SRXN1 in OVARY (Pearson r = 0.50).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	SRXN1 →	+0.964	+0.832	.003	.008	3	4
BLOOD_Myeloma	TTLL12 →	+0.904	+0.317	.004	.005	3	3
BLOOD_Myeloma	DGLUCY →	-0.977	-0.230	<.001	.004	3	3
BLOOD_Myeloma	CIAO2B →	+0.823	+0.256	.008	.003	3	3
KIDNEY	OAZ2 →	+0.656	+0.262	.006	.009	3	3
LUNG_NSCLC_LUAD	HEXB →	+0.526	+0.169	.007	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010881 vs SRXN1 — OVARY

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