Retina layer formation

Across TCGA patient cohorts, RNA activity of the Retina layer formation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RFC4, SAMHD1_S33, and LSR, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retina layer formation activity versus RFC4 in OV (Pearson r = -0.30).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RFC4 →	-0.350	-0.050	.002	.002	3	6
GBM	SAMHD1_S33 →	-0.496	-0.056	.003	.007	3	5
LUAD	LSR →	+0.340	+0.056	.001	.006	3	5
GBM	PARP14 →	-0.334	-0.067	.003	.006	3	5
HNSC	KRT8 →	+0.710	+0.044	<.001	<.001	3	5
GBM	ARHGAP32 →	+0.323	+0.095	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010842 vs RFC4 — OV

Explore this scatter interactively →