Retina layer formation

Across TCGA pan-cancer cohorts, RNA activity of the Retina layer formation pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 25 member genes.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher Retina layer formation pathway activity is associated with better overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as STAD and ESCA, show the opposite pattern, with higher activity associated with better survival.

STAD, ESCA, and BLCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	OS	Median	All	0.570	0.286	<.001	68	view →
ESCA	OS	Median	All	0.618	0.360	.003	25	view →
BLCA	DFS	Quartile	II,III,IV	0.432	0.269	.009	24	view →
KIRC	DFS	Median	II,III,IV	0.586	0.471	.025	23	view →
CESC	DFS	Quartile	All	0.750	0.863	.007	16	view →
UVM	DFS	Median	II,III,IV	0.854	0.617	.004	16	view →
MESO	DFS	Tertile	III,IV	0.167	0.621	.010	15	view →
LIHC	DFS	Quartile	All	0.369	0.549	.017	12	view →
CHOL	DFS	Quartile	All	0.112	0.637	.027	12	view →
DLBC	DFS	Median	II,III,IV	0.575	1.000	.021	9	view →
THCA	DFS	Median	IV	0.397	0.778	.005	8	view →
UCS	OS	Median	IV	0.735	0.320	.035	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0010842–STAD (OS)

Open the STAD breakdown →