Positive regulation of cell-substrate adhesion

Across TCGA cell cohorts, RNA activity of the Positive regulation of cell-substrate adhesion pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP2W1, TEAD1, and TLN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP2W1 grouped by Positive regulation of cell-substrate adhesion-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CYP2W1 →	-0.246	-0.107	.003	.002	2	7
STOMACH	TEAD1 →	+0.601	+0.125	.009	.002	3	6
STOMACH	TLN1 →	+0.570	+0.119	<.001	<.001	3	6
LUNG_NSCLC_LUSC	PLRG1 →	-0.376	-0.145	<.001	<.001	3	6
STOMACH	UFC1 →	+0.270	+0.092	<.001	<.001	3	6
BREAST	SOX11 →	-0.205	-0.074	.007	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP2W1 by Positive regulation of cell-substrate adhesion activity — CNS

Explore this box plot interactively →