Positive regulation of peptidyl-threonine phosphorylation

Across TCGA patient cohorts, RNA activity of the Positive regulation of peptidyl-threonine phosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNKS1BP1, GJB2, and CEP97, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of peptidyl-threonine phosphorylation activity versus TNKS1BP1 in HNSC (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TNKS1BP1 →	+0.831	+0.307	<.001	<.001	3	7
HNSC	GJB2 →	+1.310	+0.212	<.001	<.001	3	7
LSCC	CEP97 →	-0.448	-0.197	<.001	<.001	3	6
HNSC	UPP1 →	+1.560	+0.298	<.001	<.001	3	6
HNSC	NSL1 →	-0.475	-0.223	.002	<.001	3	6
HNSC	TNFRSF12A →	+1.046	+0.212	.005	.004	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010800 vs TNKS1BP1 — HNSC

Explore this scatter interactively →