Positive regulation of peptidyl-threonine phosphorylation

Across TCGA pan-cancer cohorts, RNA activity of the Positive regulation of peptidyl-threonine phosphorylation pathway is associated with patient survival in 28 of 34 cancer lineages. Pathway activity is summarized from the expression of its 29 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Positive regulation of peptidyl-threonine phosphorylation pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and DLBC, show the opposite pattern, with higher activity associated with better survival.

UVM, MESO, and ACC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.392	0.723	<.001	128	view →
MESO	OS	Median	All	0.275	0.498	<.001	98	view →
ACC	OS	Tertile	II,III,IV	0.526	0.918	<.001	94	view →
KIRC	OS	Median	All	0.746	0.849	<.001	93	view →
HNSC	OS	Tertile	All	0.474	0.328	.004	65	view →
BLCA	OS	Quartile	All	0.524	0.729	.004	50	view →
LGG	DFS	Tertile	All	0.304	0.545	<.001	34	view →
LUAD	OS	Tertile	All	0.674	0.826	.008	29	view →
UCS	OS	Median	II,III,IV	0.246	0.654	.012	28	view →
DLBC	DFS	Median	All	0.809	0.310	.003	14	view →
BRCA	DFS	Quartile	IV	0.218	0.892	.020	12	view →
SKCM	OS	Median	II,III,IV	0.440	0.268	.005	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

GO:0010800–UVM (DFS)

Open the UVM breakdown →