Regulation of mRNA export from nucleus

Across TCGA cell cohorts, RNA activity of the Regulation of mRNA export from nucleus pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RABEP1, CCDC28A-AS1, and PIMREG, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mRNA export from nucleus activity versus RABEP1 in LARGE_INTESTINE (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RABEP1 →	+1.072	+1.183	<.001	.001	3	6
PANCREAS	CCDC28A-AS1 →	+0.419	+1.421	.001	<.001	3	6
OVARY	PIMREG →	+1.059	+1.163	.008	<.001	3	6
LUNG_NSCLC_LUAD	RUVBL1 →	+0.480	+0.747	.002	.002	3	6
LARGE_INTESTINE	PAICS →	+1.133	+1.164	.001	.002	3	6
BREAST	CDCA5 →	+0.793	+0.901	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010793 vs RABEP1 — LARGE_INTESTINE

Explore this scatter interactively →