Negative regulation of cGMP-mediated signaling

Across TCGA cell cohorts, RNA activity of the Negative regulation of cGMP-mediated signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAX, UBE2M, and BLOC1S5-TXNDC5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAX grouped by Negative regulation of cGMP-mediated signaling-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MAX →	-0.604	-2.602	.003	<.001	3	5
SOFT_TISSUE	UBE2M →	-0.208	-1.770	.006	<.001	3	4
SOFT_TISSUE	BLOC1S5-TXNDC5 →	-0.295	-1.550	.004	.003	3	4
CNS	PROCR →	-0.273	-0.918	<.001	.006	3	4
OVARY	DGKQ →	-0.203	-1.016	.002	.002	3	4
LARGE_INTESTINE	GALNT10 →	-0.261	-1.297	.003	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAX by Negative regulation of cGMP-mediated signaling activity — BONE

Explore this box plot interactively →