Negative regulation of cGMP-mediated signaling

Across TCGA pan-cancer cohorts, RNA activity of the Negative regulation of cGMP-mediated signaling pathway is associated with patient survival in 25 of 34 cancer lineages. Pathway activity is summarized from the expression of its 5 member genes.

The strongest signal is observed in uveal melanoma (UVM), where higher Negative regulation of cGMP-mediated signaling pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as KIRC and LIHC, show the opposite pattern, with higher activity associated with better survival.

UVM, KIRC, and LIHC are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	II,III,IV	0.333	0.747	<.001	99	view →
KIRC	OS	Median	All	0.917	0.832	<.001	60	view →
LIHC	OS	Quartile	All	0.892	0.698	.001	38	view →
LAML	DFS	Quartile	All	0.288	0.596	.001	34	view →
READ	OS	Median	II,III,IV	1.000	0.812	.005	26	view →
PAAD	DFS	Median	II,III,IV	0.344	0.584	.003	18	view →
BLCA	DFS	Tertile	III,IV	0.558	0.373	.006	17	view →
PRAD	DFS	Median	All	0.868	0.706	.008	14	view →
CESC	OS	Quartile	III,IV	0.255	0.793	.014	12	view →
ESCA	DFS	Tertile	II,III,IV	1.000	0.127	.010	12	view →
LGG	DFS	Quartile	All	0.867	0.770	.009	10	view →
MESO	OS	Median	IV	0.386	0.728	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

GO:0010754–UVM (OS)

Open the UVM breakdown →