Regulation of extracellular matrix disassembly

Across TCGA cell cohorts, RNA activity of the Regulation of extracellular matrix disassembly pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLRG1, IQSEC3, and WDR91, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLRG1 grouped by Regulation of extracellular matrix disassembly-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PLRG1 →	-0.310	-0.122	.007	.006	3	5
PANCREAS	IQSEC3 →	+0.204	+0.136	<.001	.002	3	5
LUNG_SCLC	WDR91 →	-0.159	-0.165	.001	<.001	3	5
BLOOD_Leukemia	TUB →	+0.188	+0.130	.009	.001	3	5
LARGE_INTESTINE	PIK3R4 →	-0.150	-0.074	<.001	.001	3	5
LARGE_INTESTINE	PSG11 →	+0.232	+0.096	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLRG1 by Regulation of extracellular matrix disassembly activity — LUNG_SCLC

Explore this box plot interactively →