Negative regulation of collagen metabolic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of collagen metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TOMM70, DTD2, and GOT1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of collagen metabolic process activity versus TOMM70 in BLOOD_Lymphoma (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TOMM70 →	+1.158	+1.255	.008	.003	3	6
LUNG_NSCLC_LUSC	DTD2 →	+1.065	+1.067	.001	.002	3	6
BLOOD_Leukemia	GOT1 →	+1.050	+1.046	.003	<.001	3	6
BLOOD_Lymphoma	MCM7 →	+1.700	+1.205	<.001	.002	3	6
LUNG_SCLC	EEF1AKMT4 →	+0.968	+1.191	<.001	<.001	3	5
SOFT_TISSUE	FEM1A →	+0.756	+1.152	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010713 vs TOMM70 — BLOOD_Lymphoma

Explore this scatter interactively →