Epithelial structure maintenance

Across TCGA patient cohorts, RNA activity of the Epithelial structure maintenance pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are BIN3, HEATR1, and KPNA2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Epithelial structure maintenance activity versus BIN3 in BRCA (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BIN3 →	+0.501	+0.043	<.001	<.001	3	6
BRCA	HEATR1 →	-0.301	-0.037	<.001	<.001	3	6
BRCA	KPNA2 →	-0.780	-0.044	<.001	<.001	3	6
BRCA	BBS7 →	+0.471	+0.051	<.001	<.001	3	6
BRCA	WDR36 →	-0.266	-0.038	<.001	<.001	3	6
BRCA	XPO5 →	-0.425	-0.031	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010669 vs BIN3 — BRCA

Explore this scatter interactively →