Epithelial structure maintenance

Across TCGA cell cohorts, RNA activity of the Epithelial structure maintenance pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAMAC, TGFBI, and FCSK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAMAC grouped by Epithelial structure maintenance-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	RAMAC →	-0.516	-0.795	.005	.005	2	5
SKIN	TGFBI →	+3.880	+0.962	.001	<.001	3	4
BREAST	FCSK →	-0.851	-0.792	.001	.003	3	3
BREAST	C15orf40 →	-0.638	-0.928	.004	<.001	3	3
SKIN	RNF217 →	+0.487	+0.914	.005	<.001	3	3
OVARY	ANKRD12 →	+0.783	+0.966	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAMAC by Epithelial structure maintenance activity — BREAST

Explore this box plot interactively →