Negative regulation of platelet-derived growth factor receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of platelet-derived growth factor receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ISM2, MMD, and GORASP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ISM2 grouped by Negative regulation of platelet-derived growth factor receptor signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	ISM2 →	-0.136	-0.183	.005	.004	3	4
SOFT_TISSUE	MMD →	+0.321	+0.355	<.001	<.001	3	4
PANCREAS	GORASP2 →	+0.255	+1.426	.002	.004	3	3
PANCREAS	UMODL1 →	+0.233	+1.444	.001	.002	3	3
PANCREAS	ARF5 →	+0.165	+1.055	.001	.004	3	3
PANCREAS	DLX6 →	-0.155	-1.286	.005	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ISM2 by Negative regulation of platelet-derived growth factor receptor signaling pathway activity — LUNG_NSCLC_LUAD

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