Regulation of mitochondrial fusion

Across TCGA patient cohorts, RNA activity of the Regulation of mitochondrial fusion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC14, PRICKLE3, and SLC6A8, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of mitochondrial fusion activity versus TTC14 in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TTC14 →	+0.672	+0.720	.002	<.001	3	5
HNSC	PRICKLE3 →	+0.626	+0.674	.003	<.001	3	4
HNSC	SLC6A8 →	+0.937	+0.431	.002	.007	3	4
HNSC	ETNK2 →	+0.719	+0.569	.001	<.001	3	4
HNSC	CASK →	+0.541	+0.746	.001	<.001	3	4
LSCC	POLR2H →	+0.696	+1.031	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010635 vs TTC14 — HNSC

Explore this scatter interactively →