Regulation of mitochondrial fusion

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of mitochondrial fusion pathway is associated with patient survival in 22 of 34 cancer lineages. Pathway activity is summarized from the expression of its 12 member genes.

The strongest signal is observed in mesothelioma (MESO), where higher Regulation of mitochondrial fusion pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as LUSC and READ, show the opposite pattern, with higher activity associated with better survival.

MESO, LUSC, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	DFS	Median	All	0.270	0.446	.001	77	view →
LUSC	OS	Median	All	0.470	0.345	.001	57	view →
THCA	DFS	Tertile	II,III,IV	0.687	0.935	<.001	48	view →
STAD	DFS	Median	II,III,IV	0.572	0.704	.004	33	view →
UVM	DFS	Quartile	III,IV	0.142	0.792	.004	28	view →
LIHC	OS	Median	All	0.605	0.783	<.001	28	view →
COAD	DFS	Quartile	All	0.357	0.584	.007	25	view →
READ	OS	Tertile	III,IV	0.940	0.416	.016	10	view →
BRCA	OS	Median	IV	0.908	0.418	.009	8	view →
SARC	OS	Median	All	0.445	0.697	.007	6	view →
LUAD	DFS	Median	IV	0.332	0.761	.002	6	view →
ESCA	DFS	Tertile	IV	0.704	0.325	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

GO:0010635–MESO (DFS)

Open the MESO breakdown →