miRNA metabolic process

Across TCGA cell cohorts, RNA activity of the miRNA metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GORAB, RNASE1, and GOLGA6L4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GORAB grouped by miRNA metabolic process-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GORAB →	+0.404	+0.250	.008	.007	3	4
LARGE_INTESTINE	RNASE1 →	+2.624	+0.226	<.001	.004	3	4
KIDNEY	GOLGA6L4 →	+0.497	+0.275	.007	.009	2	4
LUNG_SCLC	SSR3 →	+1.025	+0.332	.002	<.001	3	3
LUNG_SCLC	NTS →	+4.395	+0.288	.008	.001	3	3
CNS	SFT2D1 →	+0.602	+0.273	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GORAB by miRNA metabolic process activity — BREAST

Explore this box plot interactively →