Regulation of cellular ketone metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of cellular ketone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NGRN, LYSMD4, and MAN2A2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NGRN grouped by Regulation of cellular ketone metabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NGRN →	+0.991	+1.272	.003	.002	3	4
LIVER	LYSMD4 →	+1.409	+1.230	<.001	.005	3	4
LIVER	MAN2A2 →	+1.528	+1.250	.001	.003	3	4
LUNG_NSCLC_LUSC	AGO4 →	+1.203	+0.214	.001	.005	3	3
LIVER	NABP1 →	-1.801	-1.243	.005	.002	2	4
LIVER	ARIH1 →	+0.609	+1.221	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NGRN by Regulation of cellular ketone metabolic process activity — LIVER

Explore this box plot interactively →