Regulation of cellular ketone metabolic process

Across TCGA pan-cancer cohorts, RNA activity of the Regulation of cellular ketone metabolic process pathway is associated with patient survival in 16 of 34 cancer lineages. Pathway activity is summarized from the expression of its 144 member genes.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher Regulation of cellular ketone metabolic process pathway activity is associated with poorer overall survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as COAD and READ, show the opposite pattern, with higher activity associated with better survival.

UCEC, LGG, and THCA are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	0.613	0.848	<.001	96	view →
LGG	OS	Tertile	All	0.296	0.522	<.001	53	view →
THCA	OS	Quartile	All	0.648	0.948	<.001	50	view →
CESC	DFS	Tertile	II,III,IV	0.513	0.804	.002	46	view →
LAML	DFS	Median	All	0.417	0.659	.005	30	view →
LUAD	DFS	Quartile	IV	0.388	0.747	.022	18	view →
ESCA	OS	Tertile	All	0.609	0.809	.004	15	view →
GBM	DFS	Quartile	All	0.157	0.381	.012	12	view →
CHOL	OS	Tertile	II,III,IV	0.355	0.869	.006	9	view →
COAD	OS	Quartile	All	0.918	0.776	.026	9	view →
STAD	OS	Tertile	II,III,IV	0.598	0.786	.043	6	view →
READ	OS	Median	II,III,IV	0.798	0.480	.032	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

GO:0010565–UCEC (OS)

Open the UCEC breakdown →