Regulation of cellular ketone metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of cellular ketone metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPEG, MSRA, and BRD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of cellular ketone metabolic process activity versus SPEG in BLOOD_Leukemia (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPEG →	-2.112	-0.213	<.001	<.001	3	5
BLOOD_Leukemia	MSRA →	+1.032	+0.121	.003	.004	3	5
OESOPHAGUS	BRD1 →	-1.404	-0.282	<.001	.003	3	5
LUNG_NSCLC_LUAD	GRHL1 →	-1.455	-0.173	<.001	.001	3	5
BLOOD_Lymphoma	ZNF460 →	-0.891	-0.174	.006	.004	3	5
OESOPHAGUS	TSC22D2 →	-1.001	-0.382	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010565 vs SPEG — BLOOD_Leukemia

Explore this scatter interactively →