Regulation of gastrulation

Across TCGA patient cohorts, RNA activity of the Regulation of gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZCCHC24, TPM1, and ITGBL1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gastrulation activity versus ZCCHC24 in OV (Pearson r = 0.02).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	ZCCHC24 →	+1.286	+0.496	<.001	.003	3	8
OV	TPM1 →	+1.171	+0.733	<.001	<.001	3	7
OV	ITGBL1 →	+0.972	+0.412	<.001	.004	3	7
OV	LINC00702 →	+0.561	+0.562	<.001	.001	3	7
OV	MEOX2 →	+1.515	+0.742	<.001	<.001	3	7
OV	MAGI2-AS3 →	+1.139	+0.604	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010470 vs ZCCHC24 — OV

Explore this scatter interactively →