Response to gamma radiation

Across TCGA cell cohorts, RNA activity of the Response to gamma radiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB8, TRMT112, and EAF2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to gamma radiation activity versus HSPB8 in URINARY_TRACT (Pearson r = -0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	HSPB8 →	-3.325	-0.271	.008	.005	3	4
SKIN	TRMT112 →	+0.784	+0.197	.001	.001	3	4
BLOOD_Lymphoma	EAF2 →	+2.197	+0.225	.001	.001	3	4
CNS	SOCS5 →	-1.035	-0.203	.003	.005	3	4
UPPER_AERODIGESTIVE_TRACT	LACC1 →	+0.848	+0.217	.007	.003	3	4
URINARY_TRACT	DAPK1 →	-4.221	-0.346	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010332 vs HSPB8 — URINARY_TRACT

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