Response to gamma radiation

Across TCGA pan-cancer cohorts, RNA activity of the Response to gamma radiation pathway is associated with patient survival in 21 of 34 cancer lineages. Pathway activity is summarized from the expression of its 51 member genes.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher Response to gamma radiation pathway activity is associated with better disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as HNSC and SCLC, show the opposite pattern, with higher activity associated with better survival.

HNSC, KIRC, and LGG are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.467	0.233	<.001	95	view →
KIRC	OS	Median	All	0.543	0.689	<.001	64	view →
LGG	OS	Median	All	0.354	0.539	<.001	54	view →
UVM	DFS	Tertile	All	0.318	0.665	.005	51	view →
SCLC	DFS	Quartile	All	0.663	0.311	.003	43	view →
SKCM	OS	Quartile	IV	0.861	0.391	.005	35	view →
READ	OS	Quartile	All	0.872	0.362	<.001	33	view →
UCS	DFS	Median	II,III,IV	0.516	0.151	.002	32	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.522	.002	29	view →
LIHC	OS	Median	All	0.411	0.642	<.001	27	view →
KIRP	DFS	Tertile	All	0.771	0.916	.003	21	view →
BLCA	DFS	Tertile	II,III,IV	0.438	0.559	.026	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GO:0010332–HNSC (DFS)

Open the HNSC breakdown →