Establishment or maintenance of transmembrane electrochemical gradient

Across TCGA patient cohorts, RNA activity of the Establishment or maintenance of transmembrane electrochemical gradient pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CTDNEP1, RN7SKP11, and MED24, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Establishment or maintenance of transmembrane electrochemical gradient activity versus CTDNEP1 in LUAD (Pearson r = -0.25).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CTDNEP1 →	-0.383	-0.194	.002	.007	3	4
LSCC	RN7SKP11 →	-0.360	-0.210	<.001	<.001	3	4
LSCC	MED24 →	-0.325	-0.175	.001	.003	2	5
BRCA	SUSD4 →	+1.060	+0.143	.008	.001	3	4
BRCA	ATP1A1 →	+0.595	+0.125	.002	.005	3	4
LUAD	RIN3 →	-0.382	-0.182	.005	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0010248 vs CTDNEP1 — LUAD

Explore this scatter interactively →