Establishment or maintenance of transmembrane electrochemical gradient

Across TCGA pan-cancer cohorts, RNA activity of the Establishment or maintenance of transmembrane electrochemical gradient pathway is associated with patient survival in 27 of 34 cancer lineages. Pathway activity is summarized from the expression of its 11 member genes.

The strongest signal is observed in brain lower grade glioma (LGG), where higher Establishment or maintenance of transmembrane electrochemical gradient pathway activity is associated with poorer disease-free survival. In most high-consensus cancer types, elevated pathway activity shows an unfavorable survival association, although some cancer types, such as SKCM and LAML, show the opposite pattern, with higher activity associated with better survival.

LGG, KIRC, and SKCM are the cancer lineages in which this pathway most reproducibly stratifies patient survival.

Pathway-activity survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 represent the survival AUCs for the high- and low-pathway-activity groups, respectively. The group with the lower AUC is interpreted as having poorer survival. The reported p-values are derived from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.288	0.483	<.001	54	view →
KIRC	OS	Median	All	0.753	0.844	<.001	51	view →
SKCM	OS	Quartile	All	0.406	0.226	<.001	34	view →
LAML	DFS	Quartile	All	0.671	0.283	<.001	30	view →
UCS	DFS	Quartile	III,IV	0.225	0.649	.008	24	view →
CESC	OS	Tertile	All	0.692	0.837	.006	24	view →
UVM	DFS	Median	III,IV	0.346	0.739	.001	24	view →
STAD	OS	Median	III,IV	0.724	0.544	.007	15	view →
LIHC	DFS	Quartile	All	0.435	0.594	.018	12	view →
BRCA	OS	Tertile	III,IV	0.760	0.878	.018	11	view →
PAAD	OS	Quartile	All	0.479	0.749	.022	9	view →
ESCA	OS	Quartile	II,III,IV	0.361	0.616	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

GO:0010248–LGG (DFS)

Open the LGG breakdown →